> 2019 Fall semester (Updated: 2019-11-01)
19-08-09 (FRI): SEMESTER OVERVIEW
19-08-16 (FRI): AUG SYMPOSIUM
19-08-23 (FRI): All undergrads
19-08-30 (FRI): DSB: Gehringer, M.; Laufer, S. A., Emerging and re-emerging warheads for targeted covalent inhibitors: applications in medicinal chemistry and chemical biology. J. Med. Chem. 2018, 62 (12), 5673-5724.
19-09-06 (FRI): LAPC: Vulic, K.; Shoichet, M. S., Affinity-based drug delivery systems for tissue repair and regeneration. Biomacromolecules 2014, 15 (11), 3867-3880.
19-09-13 (FRI): SEPT SYMPOSIUM
19-09-20 (FRI): LB: Alterio, V.; Di Fiore, A.; D’Ambrosio, K.; Supuran, C. T.; De Simone, G., Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? Chem. Rev. 2012, 112 (8), 4421-4468.
19-09-27 (FRI): APC: Heinen, L.; Heuser, T.; Steinschulte, A.; Walther, A., Antagonistic enzymes in a biocatalytic pH feedback system program autonomous DNA hydrogel life cycles. Nano Lett. 2017, 17 (8), 4989-4995.
19-10-04 (FRI): GRR: Aumiller Jr, W. M.; Keating, C. D., Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles. Nat. Chem. 2016, 8 (2), 129-137.
19-10-11 (FRI): JMR: Mini-tutorial on thermoresponsive materials & phase transitions [Resource: Zhang, Q.; Weber, C.; Schubert, U. S.; Hoogenboom, R., Thermoresponsive polymers with lower critical solution temperature: from fundamental aspects and measuring techniques to recommended turbidimetry conditions. Mater. Horiz. 2017, 4 (2), 109-116]
19-10-18 (FRI): OCT SYMPOSIUM
19-10-25 (FRI): MSRC Open House
19-11-01 (FRI): JAR: Chatani, S.; Sheridan, R. J.; Podgórski, M.; Nair, D. P.; Bowman, C. N., Temporal control of thiol-click chemistry. Chem. Mater. 2013, 25 (19), 3897-3901.
19-11-08 (FRI): MAS: Okur, H. I.; Hladilkova, J.; Rembert, K. B.; Cho, Y.; Heyda, J.; Dzubiella, J.; Cremer, P. S.; Jungwirth, P., Beyond the Hofmeister series: Ion-specific effects on proteins and their biological functions. J. Phys. Chem. B 2017, 121 (9), 1997-2014.
- VAB: Yoshii, T.; Mizusawa, K.; Takaoka, Y.; Hamachi, I., Intracellular protein-responsive supramolecules: protein sensing and in-cell construction of inhibitor assay system. J. Am. Chem. Soc. 2014, 136 (47), 16635-16642.
- MER: W. Lin, L. Long, L. Yuan, Z. Cao, B. Chen and W. Tan, A ratiometric fluorescent probe for cysteine and homocysteine displaying a large emission shift. Org. Lett., 2008, 10, 5577–5580.
19-11-22 (FRI): NOV SYMPOSIUM
19-11-29 (FRI): THANKSGIVING WEEKEND 🦃
19-12-06 (FRI): TBA
19-12-13 (FRI): FALL SEMESTER SYMPOSIUM
> 2018 Spring semester
- 03-16. MAS: Graduate seminar practice
- 03-23. **March symposium: Part 1**
- 03-28. **March symposium: Part 2**
- 03-30. No meeting (Good Friday)
- 04-06. DSB, RAB, VAB: Kanza, 2017. Electronic lab notebooks: can they replace paper?
- 04-18 (WED; 6:00 PM). JTM-PRISM 2018 practice #1
- 04-25 (WED; 5:00 PM). JTM-PRISM 2018 practice #2
- LAPC: Heyda, 2017. Guanidinium can both Cause and Prevent the Hydrophobic Collapse of BiomacromoleculesRead Luis’ comment
- MER: Li, 2018. Synthesis and Direct Observation of Thermoresponsive DNA CopolymersRead Minelise’s comment
- VAB: Tang, 2016. Reversible Regulation of Thermoresponsive Property of Dithiomaleimide-Containing Copolymers via Sequential Thiol Exchange ReactionsRead Valeria’s comment
- DSB: Quiroz, 2015. Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymersRead Diana’s comment
- JMM: Tanaka, 2017. Intelligent, Biodegradable, and Self-Healing Hydrogels Utilizing DNA QuadruplexesRead José’s comment
- KNV: Aikawa, 2017. A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pHRead Kiara’s comment
- MAS: Sakota, 2015. Macromolecular Crowding Modifies the Impact of Specific Hofmeister Ions on the Coil–Globule Transition of PNIPAMRead Maxier’s comment
- MLAC: Kim, 2015. Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular TransportRead María’s comment
- RAB: Li, 2018. Thermal Switching of Thermoresponsive Polymer Aqueous SolutionsRead Rafa’s comment
- CMQ: Tang, 2017. Active Targeting of the Nucleus Using Nonpeptidic Boronate TagsRead Carla’s comment
- MIO: Yang, 2012. Reversible Changes in Solution pH Resulting from Changes in Thermoresponsive Polymer SolubilityRead Miriam’s comment
- 06-01. **Spring semester symposium**
- 06-08. No meeting (Spring semester finals)
- 06-15. TBA
- 06-22. TBA
- 06-29. TBA
- 07-06. TBA
- 07-13. TBA
- 07-20. TBA
- 07-27. TBA
> 2017 Fall semester
- 11-03. MCRS: Zhou, 2017. Unexpected Position-Dependent Effects of Ribose G-Quartets in G-Quadruplexes
- 11-10. DSB: Banani, 2016. Compositional Control of Phase-Separated Cellular Bodies [PMC4967043]
- 11-17. **November symposium**
- 11-24. Thanksgiving holiday
- 12-01. LAPC: Tan, 2017. Reaction-Based Off–On Near-infrared Fluorescent Probe for Imaging Alkaline Phosphatase Activity in Living Cells and Mice
- 12-08. JMM: Manna, 2017. Probing Human Telomeric DNA and RNA Topology and Ligand Binding in a Cellular Model by Using Responsive Fluorescent Nucleoside Probes
- 12-15. LB: Wei, 2017. Super-multiplex vibrational imaging
- 12-22. **Fall semester symposium**
- 12-29. No meeting
- 01-05. No meeting
- 01-12. (1) VAB: Liu, 2017. A Reversible Fluorescent Probe for Real-Time Quantitative Monitoring of Cellular Glutathione; (2) LAPC: RISE presentation rehersal
- 01-19. MER: Fadock, 2017. DNA Aptamer−Target Binding Motif Revealed Using a Fluorescent Guanine Probe: Implications for Food Toxin Detection [OA]
- 01-26. RAB: Beck, 2017. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylasesin live cells and tissues [OA]
- 02-02. **February symposium**
- 02-09. MAS: Fernandez, 2017. Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates [OA]
- 02-16. MIO: Miljanić, 2017. Assessment of human telomeric G-quadruplex structures using surface-enhanced Raman spectroscopy
- 02-23. No meeting (“Fall” semester finals)
> 2017 Spring semester group meeting schedule (Updated: 2017-05-16)
- 02-24: DSB: Pak, 2016. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein; DDM: MARC presentation practice
- 03-03: MCRS: Cammas, 2016. RNA G-quadruplexes: emerging mechanisms in disease
- 03-10: LB: Hoffman, 2013. A New Raman Spectroscopic Probe of Both the Protonation State and Noncovalent Interactions of Histidine Residues; YRV: Bai, 2015. Chemical Control over Cellular Uptake of Organic Nanoparticles by Fine Tuning Surface Functional Groups
- 03-17: LAPC: Levine, 2013. Functional Roles of Pulsing in Genetic Circuits
- 03-31: March research symposium (all except MCRS)
- 04-03: MCRS: Thesis presentation practice
- 04-07: DDM: Krenske, 2016. Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines
- 04-14: Spring break
- 04-21: JTM/PRISM practice (undergrads)
- 04-28: April research symposium (grads); MLA JTM/PRISM practice
- 05-05: ANA & MLA: Lu, 2014. Stimuli-responsive nanomaterials for therapeutic protein delivery
- 05-12: MAS: Lane, 2015. Physical chemistry of nanomedicine: understanding the complex behaviors of nanoparticles in vivo
- 05-19: JMR proposal writing mini-workshop
- 05-26: Spring semester symposium (all except MCRS)
> 2016 Fall semester group meeting schedule (Updated: 2016-11-27)
- Sept. 30. Proposal discussion: JMR
- Oct. 7. @UMD
- Oct. 14. Literature presentations
- MCRS: Amato, 2016. Toward the Development of Specific G‐Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives
- MAS: Zhang, 2014. Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents
- DDM: Chiang, 2015. Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer
- Oct. 21. Mid-Semester Symposium: ALL
- Oct. 28. LAPC‘s seminar practice
- Nov. 4. LB’s seminar practice; MAS proposal A practice
- Nov. 11. Veteran’s Day holiday
- Nov. 18. Literature presentations
- Nov. 25. Thanksgiving holiday
- Dec. 2. Literature presentations
- LAPC: Zhang, 2014. Biocompatible Reactive Oxygen Species (ROS)-Responsive Nanoparticles as Superior Drug Delivery Vehicles
- AVG: Deepagan, 2016. In situ diselenide-crosslinked polymeric micelles for ROS-mediated anticancer drug delivery
- LB: Farhane, 2015. Raman micro spectroscopy for in vitro drug screening: subcellular localisation and interactions of doxorubicin
- SQ: Zhang, 2015. Self-Assembled DNA Immunonanoflowers as Multivalent CpG Nanoagents
- Dec. 16. Fall Semester Symposium: ALL
> 2016 Summer (Updated: 2016-07-06)
- 2016-07-08 (FRI). Xavier’s practice for REU Symposium (9:00 AM)
- 2016-07-13 (WED). Xavier’s presentation at the REU Symposium (1:00 PM)
- 2016-07-15 (FRI). Mid Summer symposium (9:00 AM)
> 2014 Spring Semester (last updated 2014-05-01)
- 01-16. Proposal A overview (LB, LAP)
- 01-31. Research project overview. (MCRS, LMN)
- 02-07. Abstract writing workshop. (JMR)
- 02-14. Feb. Symposium 1. (LMN, LDR, LAP)
- 02-21. Feb. Symposium 2. (MCRS, LB)
- 02-28. JTM first practice. (YRV, JARC, EPP, DDM)
- 03-07. Research project overview (TLD)
- 03-14. Proposal B overview (MCRS)
- 03-21. JTM final practice. (LDR, YRV, JARC, EPP, DDM)
- 03-28. Proposal A final practice (LB, LAP)
- 04-04. Literature update. Presenting: TBA
- 04-11. Thesis defense overview (LMN)
- 04-18. Spring Break
- 04-25. Current proposal overview (JMR)
- 05-02. JMR
- 05-09. TBA
- 05-16. No meeting during this week
- 05-23. Spring Semester Symposium (All)
- 06-13. Thesis defense final practice (LMN)
> 2013 Spring Semester
Last updated 20130517
> Thursday, May 16th, 2013 (8:30 AM-12:00 PM)
> Friday, May 17th, 2013 (8:30 AM-11:00 AM)
 Mario (5 + 5)
 Ana Victoria (10 + 5)
 Loruhama (10 + 5)
 Julio (5 + 5)
 Luis Prieto (5 + 5)
 Berti (15 + 5)
 Madhavi (5 + 5)
 Gopal (15 + 5)
 Yazmary (10 + 5)
 María (15 + 5)
 Maxier (10 + 5)
 Manolo (15 + 5)
> 2012 Spring Semester (last updated 2012-02-20)
MGA; Article: Phan et al. “Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity” Nucleic Acids Res. 2011, 39, 9448–9457 (OGQ; self-assembly; structure; NMR)
MMH: Free-Energy Landscapes of Ion Movement through a G-Quadruplex DNA Channel (OGQs; cations; dynamics; computer modeling)
NZH: Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and noninvasive imaging (supramolecular; dendrimers; self-assembly)
AS: Dal Molin, M.; Gasparini, G.; Scrimin, P.; Rastrelli, F.; Prins, L. J. 13C-isotope labelling for the facilitated NMR analysis of a complex dynamic chemical system. Chem. Commun. (Camb.) 2011, 47, 12476–12478. (supramolecular; dynamic combinatorial chemistry; NMR; methods)
JCR: Khakshoor, O.; Wheeler, S. E.; Houk, K. N.; Kool, E. T. Measurement and Theory of Hydrogen Bonding Contribution to Isosteric DNA Base Pairs. J. Am. Chem. Soc. 2012. (non-covalent-interactions; DNA; H-bonds; nucleoside-derivatives)
February Symposium (Graduate students and postdocs only)
JTM/PRISM 2012 practice (Undergraduate students only)
MCRS: Dumas, A.; Luedtke, N. W. Fluorescence properties of 8-(2-pyridyl)guanine “2PyG” as compared to 2-aminopurine in DNA. ChemBioChem 2011, 12, 2044–2051. (DNA; fluorescence; fluorescent probes; OGQ; G-derivatives)
RDMR: Tran, P. L. T.; Moriyama, R.; Maruyama, A.; Rayner, B.; Mergny, J.-L. A mirror-image tetramolecular DNA quadruplex. Chem. Commun. 2011, 47, 5437–5439. (OGQ; structure; dynamics; chirality; CD)
DSB: Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S, Jackson SP. Nat Chem Biol. 2012. doi: 10.1038/nchembio.780 (OGQ; GQ-binder; genome; in vivo)
MAS: Collie, G. W.; Promontorio, R.; Hampel, S. M.; Micco, M.; Neidle, S.; Parkinson, G. N. Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J. Am. Chem. Soc. 2012. (OGQ; GQ-binder; self-assembly; structure; X-Ray)
March Symposium (AM/PM)
ACS National Meeting SD
Spring break (no meeting)
Lab business meeting
PG: Darses, B.; Greene, A. E.; Poisson, J.-F. Asymmetric Synthesis of Cyclobutanones: Synthesis of Cyclobut-G. J. Org. Chem. 2012. (synthesis; nucleosides; G-derivatives; nucleoside-derivatives; drug-development)
YMC: Gadzikwa, T.; Bellini, R.; Dekker, H. L.; Reek, J. N. H. Self-Assembly of a Confined Rhodium Catalyst for Asymmetric Hydroformylation of Unfunctionalized Internal Alkenes. J. Am. Chem. Soc. 2012, 120201163314004. (synthesis; catalysis; supramolecular)
LMN: Li, I. T. S.; Walker, G. C. Signature of hydrophobic hydration in a single polymer. Proc. Natl. Acad. Sci. USA 2011, 108, 16527–16532. (supramolecular; hydrophobicity; NCIs; single molecule; AFM; folding; thermodynamics; methods)
AVM: Pace, C. J.; Zheng, H.; Mylvaganam, R.; Kim, D.; Gao, J. Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity. Angew. Chem. Int. Ed. 2011, 51, 103–107. (non-covalent interactions; protein–protein interactions; self-assembly; stacking interactions; supramolecular)
LRR: Peng, H.-Q.; Chen, Y.-Z.; Zhao, Y.; Yang, Q.-Z.; Wu, L.-Z.; Tung, C.-H.; Zhang, L.-P.; Tong, Q.-X. Artificial Light-Harvesting System Based on Multifunctional Surface-Cross-Linked Micelles. Angew. Chem. Int. Ed. 2012, 51, 2088–2092. (click chemistry; micelles; energy transfer; light-harvesting; self-assembly; supramolecular)
LMD: Cole, E. L.; Arunkumar, E.; Xiao, S.; Smith, B. A.; Smith, B. D. Water-soluble, deep-red fluorescent squaraine rotaxanes. Org. Biomol. Chem. 2012; ASAP; DOI: 10.1039/C2OB06783H (click chemistry; fluorescence; rotaxanes; imaging probes; supramolecular)
Spring Semester Symposium: Part 1 (SSS1)
Spring Semester Symposium: Part 2 (SSS2)
Updated guidelines for article synopses and blogging… (v. 20120424.1)A. Make sure the email with your synopsis includes the following (the checklist is meant to help you keep track of the things you need to send): A word file (.doc format is preferred) with your synopsis. The font should be Arial and the font size should be 12 pt.
 Link to the original article
 Reference of the article (including the names of all the authors)
 An original (and attractive) graphical depiction of the article in jpg format. Let the picture “talk” for itself and minimize text. (NOTE: Each semester we will vote for the best synopsis and best picture. So, go ahead and get creative!)
 Link(s) to the main author(s) website(s)
 Hyperlink generously throughout your synopsis, especially for unusual terms (denoting, for examples, techniques, medicines, etc.).
 Due date: Two weeks prior to your presentationB. Guidelines to prepare a synopsis (and comments).• Article’s central idea (rationale, findings):
 What is the significance of the article?
 How novel are the results?
 What would you have done differently regarding this issue?
 What is the significance of the article?
 How novel are the results?
 Is the length of the manuscript appropriate to its contents?
 What would you have done differently regarding this point?• Experimental methods & techniques.
 Did the authors performed appropriate control experiments?
 Are the conclusions supported by the results?
 Are the references appropriate and correct?
 Whenever applicable, is the characterization provided for new compounds appropriate with regard to identity and purity?
 What would you have done differently regarding this point?• The narrative.
 Is the narrative engaging?
 Was the problem put in the proper perspective?
 Did the authors do a good job explaining the significance of their findings?
 What would you have done differently regarding this issue?C. Guidelines exclusive for comments. Everyone (except the person that wrote a given synopsis) must comment on both posts (review and article).
 Deadline for submitting your comments: Wednesday at midnight (12 AM). The presenter will evaluate the comments and address any questions and concerns. These will be incorporated in the presentation. (NOTE: Each presenter will select the best (most thoughtful and insightful) comment of their synopsis.)
 Was the synopsis well written (spelling and grammar)?
 Could a person with a general knowledge of chemistry be able to grasp the fundamentals of the article being discussed?
 Did the blogger follow guidelines?
 What do you think of the blogger’s picture?
 Did the blogger used supplementary material to aid in the understanding of his/her synopsis (e.g. hyperlinks)
 What advice can you give to the blogger to improve his/her future synopses?D. You may want to check out some these chemistry-related blogs to get in the mood for writing your synopsis: