Group Meetings

> 2019 Fall semester (Updated: 2019-11-01)

>AUG

19-08-09 (FRI): SEMESTER OVERVIEW
19-08-16 (FRI): AUG SYMPOSIUM
19-08-23 (FRI): All undergrads
19-08-30 (FRI): DSB: Gehringer, M.; Laufer, S. A., Emerging and re-emerging warheads for targeted covalent inhibitors: applications in medicinal chemistry and chemical biology. J. Med. Chem. 2018, 62 (12), 5673-5724.

>SEPT

19-09-06 (FRI): LAPC: Vulic, K.; Shoichet, M. S., Affinity-based drug delivery systems for tissue repair and regeneration. Biomacromolecules 2014, 15 (11), 3867-3880.
19-09-13 (FRI): SEPT SYMPOSIUM
19-09-20 (FRI): LB: Alterio, V.; Di Fiore, A.; D’Ambrosio, K.; Supuran, C. T.; De Simone, G., Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? Chem. Rev. 2012, 112 (8), 4421-4468.
19-09-27 (FRI): APC: Heinen, L.; Heuser, T.; Steinschulte, A.; Walther, A., Antagonistic enzymes in a biocatalytic pH feedback system program autonomous DNA hydrogel life cycles. Nano Lett. 2017, 17 (8), 4989-4995.

>OCT

19-10-04 (FRI): GRR: Aumiller Jr, W. M.; Keating, C. D., Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles. Nat. Chem. 2016, 8 (2), 129-137.
19-10-11 (FRI): JMR: Mini-tutorial on thermoresponsive materials & phase transitions [Resource: Zhang, Q.; Weber, C.; Schubert, U. S.; Hoogenboom, R., Thermoresponsive polymers with lower critical solution temperature: from fundamental aspects and measuring techniques to recommended turbidimetry conditions. Mater. Horiz. 2017, 4 (2), 109-116]
19-10-18 (FRI): OCT SYMPOSIUM
19-10-25 (FRI): MSRC Open House

>NOV

19-11-01 (FRI): JAR: Chatani, S.; Sheridan, R. J.; Podgórski, M.; Nair, D. P.; Bowman, C. N., Temporal control of thiol-click chemistry. Chem. Mater. 2013, 25 (19), 3897-3901.
19-11-08 (FRI): MAS: Okur, H. I.; Hladilkova, J.; Rembert, K. B.; Cho, Y.; Heyda, J.; Dzubiella, J.; Cremer, P. S.; Jungwirth, P., Beyond the Hofmeister series: Ion-specific effects on proteins and their biological functions. J. Phys. Chem. B 2017, 121 (9), 1997-2014.
19-11-15 (FRI):
- VAB: Yoshii, T.; Mizusawa, K.; Takaoka, Y.; Hamachi, I., Intracellular protein-responsive supramolecules: protein sensing and in-cell construction of inhibitor assay system. J. Am. Chem. Soc. 2014, 136 (47), 16635-16642.
- MER: W. Lin, L. Long, L. Yuan, Z. Cao, B. Chen and W. Tan, A ratiometric fluorescent probe for cysteine and homocysteine displaying a large emission shift. Org. Lett., 2008, 10, 5577–5580.
19-11-22 (FRI): NOV SYMPOSIUM
19-11-29 (FRI): THANKSGIVING WEEKEND 🦃

>DEC

19-12-06 (FRI): TBA
19-12-13 (FRI): FALL SEMESTER SYMPOSIUM

> 2018 Spring semester

March 2018

03-16. MAS: Graduate seminar practice
03-23. **March symposium: Part 1**
03-28. **March symposium: Part 2**
03-30. No meeting (Good Friday)

April 2018

04-06. DSB, RAB, VAB: Kanza, 2017. Electronic lab notebooks: can they replace paper?
04-13.
- LB: Petitdemange, 2017. Selective Tuning of Elastin-like Polypeptide Properties via Methionine OxidationRead Luxene’s comment
- YRV: Swaminathan, 2014. Intracellular Guest Exchange between Dynamic Supramolecular HostsRead Yanira’s comment
04-18 (WED; 6:00 PM). JTM-PRISM 2018 practice #1
04-25 (WED; 5:00 PM). JTM-PRISM 2018 practice #2

May 2018

June 2018

06-01. **Spring semester symposium**
06-08. No meeting (Spring semester finals)
06-15. TBA
06-22. TBA
06-29. TBA

July 2018

07-06. TBA
07-13. TBA
07-20. TBA
07-27. TBA

> 2017 Fall semester

October 2017

10-27.
- MLAC: Warner, 2017. A homodimer interface without base pairs in an RNA mimic of red fluorescent protein
- YRV: Feng, 2017. DNA mimics of red fluorescent proteins (RFP) based on G-quadruplex-confined synthetic RFP chromophores [OA]

November 2017

11-03. MCRS: Zhou, 2017. Unexpected Position-Dependent Effects of Ribose G-Quartets in G-Quadruplexes
11-10. DSB: Banani, 2016. Compositional Control of Phase-Separated Cellular Bodies [PMC4967043]
11-17. **November symposium**
11-24. Thanksgiving holiday

December 2017

12-01. LAPC: Tan, 2017. Reaction-Based Off–On Near-infrared Fluorescent Probe for Imaging Alkaline Phosphatase Activity in Living Cells and Mice
12-08. JMM: Manna, 2017. Probing Human Telomeric DNA and RNA Topology and Ligand Binding in a Cellular Model by Using Responsive Fluorescent Nucleoside Probes
12-15. LB: Wei, 2017. Super-multiplex vibrational imaging
12-22. **Fall semester symposium**
12-29. No meeting

January 2018

01-05. No meeting
01-12. (1) VAB: Liu, 2017. A Reversible Fluorescent Probe for Real-Time Quantitative Monitoring of Cellular Glutathione; (2) LAPC: RISE presentation rehersal
01-19. MER: Fadock, 2017. DNA Aptamer−Target Binding Motif Revealed Using a Fluorescent Guanine Probe: Implications for Food Toxin Detection [OA]
01-26. RAB: Beck, 2017. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylasesin live cells and tissues [OA]

February 2018

02-02. **February symposium**
02-09. MAS: Fernandez, 2017. Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates [OA]
02-16. MIO: Miljanić, 2017. Assessment of human telomeric G-quadruplex structures using surface-enhanced Raman spectroscopy
02-23. No meeting (“Fall” semester finals)

> 2017 Spring semester group meeting schedule (Updated: 2017-05-16)

02-24: DSB: Pak, 2016. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein; DDM: MARC presentation practice
03-03: MCRS: Cammas, 2016. RNA G-quadruplexes: emerging mechanisms in disease
03-10: LB: Hoffman, 2013. A New Raman Spectroscopic Probe of Both the Protonation State and Noncovalent Interactions of Histidine Residues; YRV: Bai, 2015. Chemical Control over Cellular Uptake of Organic Nanoparticles by Fine Tuning Surface Functional Groups
03-17: LAPC: Levine, 2013. Functional Roles of Pulsing in Genetic Circuits
03-31: March research symposium (all except MCRS)
04-03: MCRS: Thesis presentation practice
04-07: DDM: Krenske, 2016. Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines
04-14: Spring break
04-21: JTM/PRISM practice (undergrads)
04-28: April research symposium (grads); MLA JTM/PRISM practice
05-05: ANA & MLA: Lu, 2014. Stimuli-responsive nanomaterials for therapeutic protein delivery
05-12: MAS: Lane, 2015. Physical chemistry of nanomedicine: understanding the complex behaviors of nanoparticles in vivo
05-19: JMR proposal writing mini-workshop
05-26: Spring semester symposium (all except MCRS)

> 2016 Fall semester group meeting schedule (Updated: 2016-11-27)

Sept. 30. Proposal discussion: JMR
Oct. 7. @UMD
Oct. 14. Literature presentations
Oct. 21. Mid-Semester Symposium: ALL
Oct. 28. LAPC‘s seminar practice
Nov. 4. LB’s seminar practice; MAS proposal A practice
Nov. 11. Veteran’s Day holiday
Nov. 18. Literature presentations
- DSB: Zhou, 2016. Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells
- YRV: Ang, 2013. A Dual Responsive “Turn-On” Fluorophore for Orthogonal Selective Sensing of Biological Thiols and Hydrogen Peroxide
Nov. 25. Thanksgiving holiday
Dec. 2. Literature presentations
Dec. 16. Fall Semester Symposium: ALL

Useful links:

> 2016 Summer (Updated: 2016-07-06)

2016-07-08 (FRI). Xavier’s practice for REU Symposium (9:00 AM)
2016-07-13 (WED). Xavier’s presentation at the REU Symposium (1:00 PM)
2016-07-15 (FRI). Mid Summer symposium (9:00 AM)

> 2014 Spring Semester (last updated 2014-05-01)

January

01-16. Proposal A overview (LB, LAP)
01-24.
01-31. Research project overview. (MCRS, LMN)

February

02-07. Abstract writing workshop. (JMR)
02-14. Feb. Symposium 1. (LMN, LDR, LAP)
02-21. Feb. Symposium 2. (MCRS, LB)
02-28. JTM first practice. (YRV, JARC, EPP, DDM)

March

03-07. Research project overview (TLD)
03-14. Proposal B overview (MCRS)
03-21. JTM final practice. (LDR, YRV, JARC, EPP, DDM)
03-28. Proposal A final practice (LB, LAP)

April

04-04. Literature update. Presenting: TBA
04-11. Thesis defense overview (LMN)
04-18. Spring Break
04-25. Current proposal overview (JMR)

May

05-02. JMR
05-09. TBA
05-16. No meeting during this week
05-23. Spring Semester Symposium (All)
06-13. Thesis defense final practice (LMN)

> 2013 Spring Semester

Last updated 20130517

• May

> Thursday, May 16th, 2013 (8:30 AM-12:00 PM)
> Friday, May 17th, 2013 (8:30 AM-11:00 AM)

[] Mario (5 + 5)
[] Ana Victoria (10 + 5)
[] Loruhama (10 + 5)
[] Julio (5 + 5)
[] Luis Prieto (5 + 5)
[] Berti (15 + 5)
[] Madhavi (5 + 5)
[] Gopal (15 + 5)
[] Yazmary (10 + 5)
[] María (15 + 5)
[] Maxier (10 + 5)
[] Manolo (15 + 5)

> 2012 Spring Semester (last updated 2012-02-20)

• February

> 20120203

MGA; Article: Phan et al. “Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity” Nucleic Acids Res. 2011, 39, 9448–9457 (OGQ; self-assembly; structure; NMR)

> 20120210

MMH: Free-Energy Landscapes of Ion Movement through a G-Quadruplex DNA Channel (OGQs; cations; dynamics; computer modeling)

NZH: Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and noninvasive imaging (supramolecular; dendrimers; self-assembly)

> 20120217

AS: Dal Molin, M.; Gasparini, G.; Scrimin, P.; Rastrelli, F.; Prins, L. J. 13C-isotope labelling for the facilitated NMR analysis of a complex dynamic chemical system. Chem. Commun. (Camb.) 2011, 47, 12476–12478. (supramolecular; dynamic combinatorial chemistry; NMR; methods)

JCR: Khakshoor, O.; Wheeler, S. E.; Houk, K. N.; Kool, E. T. Measurement and Theory of Hydrogen Bonding Contribution to Isosteric DNA Base Pairs. J. Am. Chem. Soc. 2012. (non-covalent-interactions; DNA; H-bonds; nucleoside-derivatives)

> 20120224

February Symposium (Graduate students and postdocs only)

• March

> 20120302

JTM/PRISM 2012 practice (Undergraduate students only)

> 20120309

MCRS: Dumas, A.; Luedtke, N. W. Fluorescence properties of 8-(2-pyridyl)guanine “2PyG” as compared to 2-aminopurine in DNA. ChemBioChem 2011, 12, 2044–2051. (DNA; fluorescence; fluorescent probes; OGQ; G-derivatives)

RDMR: Tran, P. L. T.; Moriyama, R.; Maruyama, A.; Rayner, B.; Mergny, J.-L. A mirror-image tetramolecular DNA quadruplex. Chem. Commun. 2011, 47, 5437–5439. (OGQ; structure; dynamics; chirality; CD)

> 20120316:

DSB: Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S, Jackson SP. Nat Chem Biol. 2012. doi: 10.1038/nchembio.780 (OGQ; GQ-binder; genome; in vivo)

MAS: Collie, G. W.; Promontorio, R.; Hampel, S. M.; Micco, M.; Neidle, S.; Parkinson, G. N. Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J. Am. Chem. Soc. 2012. (OGQ; GQ-binder; self-assembly; structure; X-Ray)

> 20120323

March Symposium (AM/PM)

20120330

ACS National Meeting SD

• April

> 20120406

Spring break (no meeting)

> 20120413

Lab business meeting

> 20120420

PG: Darses, B.; Greene, A. E.; Poisson, J.-F. Asymmetric Synthesis of Cyclobutanones: Synthesis of Cyclobut-G. J. Org. Chem. 2012. (synthesis; nucleosides; G-derivatives; nucleoside-derivatives; drug-development)

YMC: Gadzikwa, T.; Bellini, R.; Dekker, H. L.; Reek, J. N. H. Self-Assembly of a Confined Rhodium Catalyst for Asymmetric Hydroformylation of Unfunctionalized Internal Alkenes. J. Am. Chem. Soc. 2012, 120201163314004. (synthesis; catalysis; supramolecular)

> 20120427

LMN: Li, I. T. S.; Walker, G. C. Signature of hydrophobic hydration in a single polymer. Proc. Natl. Acad. Sci. USA 2011, 108, 16527–16532. (supramolecular; hydrophobicity; NCIs; single molecule; AFM; folding; thermodynamics; methods)

AVM: Pace, C. J.; Zheng, H.; Mylvaganam, R.; Kim, D.; Gao, J. Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity. Angew. Chem. Int. Ed. 2011, 51, 103–107. (non-covalent interactions; protein–protein interactions; self-assembly; stacking interactions; supramolecular)

• May

> 20120504

LRR: Peng, H.-Q.; Chen, Y.-Z.; Zhao, Y.; Yang, Q.-Z.; Wu, L.-Z.; Tung, C.-H.; Zhang, L.-P.; Tong, Q.-X. Artificial Light-Harvesting System Based on Multifunctional Surface-Cross-Linked Micelles. Angew. Chem. Int. Ed. 2012, 51, 2088–2092. (click chemistry; micelles; energy transfer; light-harvesting; self-assembly; supramolecular)

LMD: Cole, E. L.; Arunkumar, E.; Xiao, S.; Smith, B. A.; Smith, B. D. Water-soluble, deep-red fluorescent squaraine rotaxanes. Org. Biomol. Chem. 2012; ASAP; DOI: 10.1039/C2OB06783H (click chemistry; fluorescence; rotaxanes; imaging probes; supramolecular)

> 20120511

Spring Semester Symposium: Part 1 (SSS1)

> 20120518

Spring Semester Symposium: Part 2 (SSS2)

> 20120525

TBA

________________________
Updated guidelines for article synopses and blogging… (v. 20120424.1)A. Make sure the email with your synopsis includes the following (the checklist is meant to help you keep track of the things you need to send):[] A word file (.doc format is preferred) with your synopsis. The font should be Arial and the font size should be 12 pt.

[] Link to the original article
[] Reference of the article (including the names of all the authors)
[] An original (and attractive) graphical depiction of the article in jpg format. Let the picture “talk” for itself and minimize text. (NOTE: Each semester we will vote for the best synopsis and best picture. So, go ahead and get creative!)
[] Link(s) to the main author(s) website(s)

[] Hyperlink generously throughout your synopsis, especially for unusual terms (denoting, for examples, techniques, medicines, etc.).
[] Due date: Two weeks prior to your presentationB. Guidelines to prepare a synopsis (and comments).• Article’s central idea (rationale, findings):
[] What is the significance of the article?
[] How novel are the results?
[] What would you have done differently regarding this issue?
[] What is the significance of the article?
[] How novel are the results?
[] Is the length of the manuscript appropriate to its contents?
[] What would you have done differently regarding this point?• Experimental methods & techniques.
[] Did the authors performed appropriate control experiments?
[] Are the conclusions supported by the results?
[] Are the references appropriate and correct?
[] Whenever applicable, is the characterization provided for new compounds appropriate with regard to identity and purity?
[] What would you have done differently regarding this point?• The narrative.
[] Is the narrative engaging?
[] Was the problem put in the proper perspective?
[] Did the authors do a good job explaining the significance of their findings?
[] What would you have done differently regarding this issue?C. Guidelines exclusive for comments.[] Everyone (except the person that wrote a given synopsis) must comment on both posts (review and article).
[] Deadline for submitting your comments: Wednesday at midnight (12 AM). The presenter will evaluate the comments and address any questions and concerns. These will be incorporated in the presentation. (NOTE: Each presenter will select the best (most thoughtful and insightful) comment of their synopsis.)
[] Was the synopsis well written (spelling and grammar)?
[] Could a person with a general knowledge of chemistry be able to grasp the fundamentals of the article being discussed?
[] Did the blogger follow guidelines?
[] What do you think of the blogger’s picture?
[] Did the blogger used supplementary material to aid in the understanding of his/her synopsis (e.g. hyperlinks)
[] What advice can you give to the blogger to improve his/her future synopses?D. You may want to check out some these chemistry-related blogs to get in the mood for writing your synopsis: